InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP21

Summary

InnateDB Protein

IDBP-92839.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP21

Protein Name

matrix metallopeptidase 21

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357798

InnateDB Gene

IDBG-92837 (MMP21)

Protein Structure

UniProt Annotation

Function

May have an important and specific function in tumor progression and embryogenesis. Cleaves alpha-1-antitrypsin.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines. {ECO:0000269PubMed:12490321, ECO:0000269PubMed:12617721}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006508	proteolysis

Cellular Component

GO:0005576	extracellular region
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References