InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENTPD2

Summary

InnateDB Protein

IDBP-93041.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENTPD2

Protein Name

ectonucleoside triphosphate diphosphohydrolase 2

Synonyms

CD39L1; NTPDase-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000347213

InnateDB Gene

IDBG-93039 (ENTPD2)

Protein Structure

UniProt Annotation

Function

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.

Subcellular Localization

Isoform Long: Cell membrane; Multi-pass membrane protein.Isoform Short: Endoplasmic reticulum membrane; Multi-pass membrane protein.Isoform gamma: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0017110	nucleoside-diphosphatase activity
GO:0017111	nucleoside-triphosphatase activity