InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAN1B1

Summary

InnateDB Protein

IDBP-93062.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAN1B1

Protein Name

mannosidase, alpha, class 1B, member 1

Synonyms

ERMAN1; MANA-ER; MRT15;

Species

Homo sapiens

Ensembl Protein

ENSP00000360645

InnateDB Gene

IDBG-93060 (MAN1B1)

Protein Structure

UniProt Annotation

Function

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). {ECO:0000269PubMed:12090241, ECO:0000269PubMed:18003979}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10409699}; Single-pass type II membrane protein {ECO:0000269PubMed:10409699}.

Disease Associations

Mental retardation, autosomal recessive 15 (MRT15) [MIM:614202]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:21763484}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10409699, ECO:0000269PubMed:10521544}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding

Biological Process

GO:0006457	protein folding
GO:0006487	protein N-linked glycosylation
GO:0009311	oligosaccharide metabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0044322	endoplasmic reticulum quality control compartment