Version 5.4
Homo sapiens Protein: DESI1
Summary
InnateDB Protein IDBP-9316.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DESI1
Protein Name PPPDE peptidase domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263256
InnateDB Gene IDBG-9314 (DESI1)
Protein Structure
UniProt Annotation
Function Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008580 PPPDE putative peptidase domain
PFAM PF05903
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ICB0
PhosphoSite PhosphoSite-Q6ICB0
TrEMBL
UniProt Splice Variant
Entrez Gene 27351
UniGene Hs.617673
RefSeq NP_056519
HUGO HGNC:24577
OMIM 614637
CCDS CCDS33652
HPRD 18590
IMGT
EMBL AL023553 BC093956 BC112179 CH471095 CR456458 Z83840
GenPept AAH93956 AAI12180 CAG30344 CAI17917 CAI20277 EAW60445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca