Homo sapiens Protein: EXD3
Summary
InnateDB Protein IDBP-93340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXD3
Protein Name exonuclease 3'-5' domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340474
InnateDB Gene IDBG-93338 (EXD3)
Protein Structure
UniProt Annotation
Function Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002562 3\'-5\' exonuclease domain
IPR002782 Mut7-C RNAse domain
IPR012337 Ribonuclease H-like domain
PFAM PF01612
PF01927
PRINTS
PIRSF
SMART SM00474
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N9H8
PhosphoSite PhosphoSite-Q8N9H8
TrEMBL E9PI94
UniProt Splice Variant
Entrez Gene 54932
UniGene Hs.495553
RefSeq NP_060290
HUGO HGNC:26023
OMIM
CCDS CCDS48066
HPRD 07906
IMGT
EMBL AB061798 AK055004 AK094438 BC037355 BC110879 BX322799
GenPept AAH37355 AAI10880 BAB70838 BAC04356 BAC10986 CAX12959