InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOXA1

Summary

InnateDB Protein

IDBP-93357.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOXA1

Protein Name

NADPH oxidase activator 1

Synonyms

NY-CO-31; p51NOX; SDCCAG31;

Species

Homo sapiens

Ensembl Protein

ENSP00000342848

InnateDB Gene

IDBG-93355 (NOXA1)

Protein Structure

UniProt Annotation

Function

Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269PubMed:12657628, ECO:0000269PubMed:12716910, ECO:0000269PubMed:14617635, ECO:0000269PubMed:14978110, ECO:0000269PubMed:15181005, ECO:0000269PubMed:15824103, ECO:0000269PubMed:17602954, ECO:0000269PubMed:19755710}.

Subcellular Localization

Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

Disease Associations

Tissue Specificity

Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon. {ECO:0000269PubMed:12716910}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016176	superoxide-generating NADPH oxidase activator activity
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0006801	superoxide metabolic process
GO:0010310	regulation of hydrogen peroxide metabolic process
GO:0043085	positive regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0060263	regulation of respiratory burst

Cellular Component

GO:0005737	cytoplasm
GO:0043020	NADPH oxidase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000270 Phox/Bem1p
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM