InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYNCRIP

Summary

InnateDB Protein

IDBP-94031.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNCRIP

Protein Name

synaptotagmin binding, cytoplasmic RNA interacting protein

Synonyms

GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1; NSAP1; PP68;

Species

Homo sapiens

Ensembl Protein

ENSP00000347380

InnateDB Gene

IDBG-94027 (SYNCRIP)

Protein Structure

UniProt Annotation

Function

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma- induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269PubMed:11051545, ECO:0000269PubMed:11134005, ECO:0000269PubMed:11352648, ECO:0000269PubMed:11574476, ECO:0000269PubMed:19029303, ECO:0000269PubMed:23071094}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11574476, ECO:0000269PubMed:17289661, ECO:0000269PubMed:19029303}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.Isoform 1: Nucleus, nucleoplasm {ECO:0000250}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250}.Isoform 2: Nucleus, nucleoplasm {ECO:0000250}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250}.Isoform 3: Nucleus, nucleoplasm {ECO:0000250}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis. {ECO:0000269PubMed:11352648}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	160 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006396	RNA processing
GO:0008380	RNA splicing
GO:0016032	viral process
GO:0017148	negative regulation of translation
GO:0070934	CRD-mediated mRNA stabilization
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070937	CRD-mediated mRNA stability complex
GO:0071013	catalytic step 2 spliceosome
GO:0071204	histone pre-mRNA 3'end processing complex
GO:0097452	GAIT complex