InnateDB Protein
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IDBP-94033.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYNCRIP
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Protein Name
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synaptotagmin binding, cytoplasmic RNA interacting protein
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Synonyms
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GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ1; NSAP1; PP68;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358635
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InnateDB Gene
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IDBG-94027 (SYNCRIP)
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Protein Structure
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Function |
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma- induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269PubMed:11051545, ECO:0000269PubMed:11134005, ECO:0000269PubMed:11352648, ECO:0000269PubMed:11574476, ECO:0000269PubMed:19029303, ECO:0000269PubMed:23071094}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11574476, ECO:0000269PubMed:17289661, ECO:0000269PubMed:19029303}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.Isoform 1: Nucleus, nucleoplasm {ECO:0000250}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250}.Isoform 2: Nucleus, nucleoplasm {ECO:0000250}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250}.Isoform 3: Nucleus, nucleoplasm {ECO:0000250}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis. {ECO:0000269PubMed:11352648}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
161
[view]
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Protein-Protein |
160
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR006535
HnRNP R/Q splicing factor
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
O60506
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PhosphoSite |
PhosphoSite-O60506
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TrEMBL |
F6UXX1
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UniProt Splice Variant |
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Entrez Gene |
10492
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UniGene |
Hs.715430
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RefSeq |
NP_006363
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HUGO |
HGNC:16918
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OMIM |
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CCDS |
CCDS5005
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HPRD |
06734
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IMGT |
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EMBL |
AF037448
AF155568
AK222776
AL136082
AY034481
AY034482
AY034483
BC015575
BC032643
BC040844
CH471051
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GenPept |
AAC12926
AAD38198
AAH15575
AAH32643
AAH40844
AAK59703
AAK59704
AAK59705
BAD96496
CAI20446
CAI20447
EAW48625
EAW48626
EAW48629
EAW48630
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