InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKIRIN2

Summary

InnateDB Protein

IDBP-94217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKIRIN2

Protein Name

akirin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000257787

InnateDB Gene

IDBG-94215 (AKIRIN2)

Protein Structure

UniProt Annotation

Function

Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18066067}.

Disease Associations

Tissue Specificity

Widely expressed with the highest expression in peripheral blood leukocytes. {ECO:0000269PubMed:18066067}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0009790	embryo development
GO:0010629	negative regulation of gene expression
GO:0010950	positive regulation of endopeptidase activity
GO:0032496	response to lipopolysaccharide
GO:0032755	positive regulation of interleukin-6 production
GO:0045087	innate immune response
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter