Version 5.4
Homo sapiens Protein: FHL5
Summary
InnateDB Protein IDBP-94465.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FHL5
Protein Name four and a half LIM domains 5
Synonyms ACT; dJ393D12.2;
Species Homo sapiens
Ensembl Protein ENSP00000326022
InnateDB Gene IDBG-94463 (FHL5)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner. {ECO:0000269PubMed:11327716}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11327716}. Note=Nuclei of round and elongated spermatids.
Disease Associations
Tissue Specificity Testis-specific (at protein level). {ECO:0000269PubMed:11327716}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5TD97
PhosphoSite PhosphoSite-
TrEMBL X6RED3
UniProt Splice Variant
Entrez Gene 9457
UniGene Hs.632608
RefSeq NP_065228
HUGO HGNC:17371
OMIM 605126
CCDS CCDS5035
HPRD 05497
IMGT
EMBL AF278541 AK057611 AK223539 AK314608 AL132776 BC021723 BC029490 CH471051
GenPept AAF85978 AAH21723 AAH29490 BAD97259 BAG37178 BAG51940 CAB86657 CAI20400 EAW48503 EAW48504 EAW48505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca