InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC9A1

Summary

InnateDB Protein

IDBP-94813.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9A1

Protein Name

solute carrier family 9 (sodium/hydrogen exchanger), member 1

Synonyms

APNH; NHE-1; NHE1; PPP1R143;

Species

Homo sapiens

Ensembl Protein

ENSP00000263980

InnateDB Gene

IDBG-94809 (SLC9A1)

Protein Structure

UniProt Annotation

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. {ECO:0000269PubMed:11350981, ECO:0000269PubMed:15035633, ECO:0000269PubMed:8901634}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Kidney and intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001101	response to acid
GO:0002026	regulation of the force of heart contraction
GO:0005975	carbohydrate metabolic process
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0010447	response to acidity
GO:0014070	response to organic cyclic compound
GO:0016049	cell growth
GO:0030154	cell differentiation
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0030307	positive regulation of cell growth
GO:0032869	cellular response to insulin stimulus
GO:0035725	sodium ion transmembrane transport
GO:0035794	positive regulation of mitochondrial membrane permeability
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0045760	positive regulation of action potential
GO:0051259	protein oligomerization
GO:0051453	regulation of intracellular pH
GO:0051930	regulation of sensory perception of pain
GO:0055007	cardiac muscle cell differentiation
GO:0055085	transmembrane transport
GO:0070997	neuron death
GO:0071236	cellular response to antibiotic
GO:0071257	cellular response to electrical stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071436	sodium ion export
GO:0071456	cellular response to hypoxia
GO:0071468	cellular response to acidity
GO:0086003	cardiac muscle cell contraction
GO:1902533	positive regulation of intracellular signal transduction
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome