InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STX12

Summary

InnateDB Protein

IDBP-95018.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX12

Protein Name

syntaxin 12

Synonyms

STX13; STX14;

Species

Homo sapiens

Ensembl Protein

ENSP00000363054

InnateDB Gene

IDBG-95016 (STX12)

Protein Structure

UniProt Annotation

Function

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endomembrane system {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016079	synaptic vesicle exocytosis
GO:0016192	vesicle-mediated transport
GO:0033344	cholesterol efflux
GO:0050821	protein stabilization

Cellular Component

GO:0000139	Golgi membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031083	BLOC-1 complex
GO:0031201	SNARE complex
GO:0045121	membrane raft
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome