Version 5.4
Homo sapiens Protein: FNTB
Summary
InnateDB Protein IDBP-9502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FNTB
Protein Name farnesyltransferase, CAAX box, beta
Synonyms FPTB;
Species Homo sapiens
Ensembl Protein ENSP00000246166
InnateDB Gene IDBG-547081 (FNTB)
Protein Structure
UniProt Annotation
Function Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO:0000269PubMed:12036349, ECO:0000269PubMed:12825937, ECO:0000269PubMed:16893176, ECO:0000269PubMed:19246009, ECO:0000269PubMed:8494894}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 10 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004311 farnesyltranstransferase activity
GO:0004660 protein farnesyltransferase activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0019840 isoprenoid binding
GO:0042277 peptide binding
Biological Process
GO:0007603 phototransduction, visible light
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010035 response to inorganic substance
GO:0014070 response to organic cyclic compound
GO:0016056 rhodopsin mediated signaling pathway
GO:0018343 protein farnesylation
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0034097 response to cytokine
GO:0042060 wound healing
GO:0045787 positive regulation of cell cycle
GO:0048146 positive regulation of fibroblast proliferation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005875 microtubule associated complex
GO:0005965 protein farnesyltransferase complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
PFAM PF00432
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49356
PhosphoSite PhosphoSite-P49356
TrEMBL Q86TX8
UniProt Splice Variant
Entrez Gene 2342
UniGene
RefSeq NP_002019
HUGO HGNC:3785
OMIM 134636
CCDS CCDS9769
HPRD 00608
IMGT
EMBL AK093298 AK295972 AK303739 AK315714 AL135745 AL139022 BC020232 BX248269 CH471061 L00635 L10414
GenPept AAA35854 AAA86286 AAH20232 BAG38073 BAG52684 BAG58748 BAG64712 CAD62597 EAW80897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca