InnateDB Protein
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IDBP-95037.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP1R8
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Protein Name
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protein phosphatase 1, regulatory subunit 8
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Synonyms
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ARD-1; ARD1; NIPP-1; NIPP1; PRO2047;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000236412
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InnateDB Gene
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IDBG-95029 (PPP1R8)
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Protein Structure
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Function |
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
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Subcellular Localization |
Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha (>90%) and isoform Beta were found in brain, heart and kidney. Isoform Gamma is mainly found in B-cells and T-lymphocytes, and has been found in 293 embryonic kidney cells. {ECO:0000269PubMed:10103062, ECO:0000269PubMed:7499293}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
44
[view]
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Protein-Protein |
43
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q12972
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PhosphoSite |
PhosphoSite-Q12972
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TrEMBL |
Q6ICT4
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UniProt Splice Variant |
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Entrez Gene |
5511
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UniGene |
Hs.618686
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RefSeq |
NP_002704
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HUGO |
HGNC:9296
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OMIM |
602636
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CCDS |
CCDS313
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HPRD |
04028
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IMGT |
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EMBL |
AF061958
AF061959
AF064751
AF064752
AF064753
AF064754
AF064755
AF064756
AF064757
AF126488
AK292077
AK297771
AK313814
AL020997
AL109927
BC001597
BC013360
CH471059
CR450309
U14575
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GenPept |
AAA64749
AAD22486
AAD24669
AAD24670
AAD31541
AAD31542
AAH01597
AAH13360
BAF84766
BAG36550
BAG60117
CAG29305
CAI20576
CAI20577
CAI20578
CAI21779
CAI21780
CAI21781
EAX07731
EAX07732
EAX07736
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