Version 5.4
Homo sapiens Protein: CENPM
Summary
InnateDB Protein IDBP-9520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPM
Protein Name centromere protein M
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000215980
InnateDB Gene IDBG-9518 (CENPM)
Protein Structure
UniProt Annotation
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. {ECO:0000269PubMed:16716197}.
Subcellular Localization Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000278 mitotic cell cycle
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR020987 Centromere protein Cenp-M
PFAM PF11111
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NSP4
PhosphoSite PhosphoSite-Q9NSP4
TrEMBL B1AHQ6
UniProt Splice Variant
Entrez Gene 79019
UniGene Hs.208912
RefSeq NP_076958
HUGO HGNC:18352
OMIM 610152
CCDS CCDS14025
HPRD 12798
IMGT
EMBL AK123479 AL160131 BC000705 BC007495 BU194618 CH471095 CR456399 CR457392 EU035297 Z99716
GenPept AAH00705 AAH07495 ABS84666 BAC85624 CAB77147 CAG30285 CAG33673 CAI41691 EAW60474 EAW60476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca