Version 5.4
Homo sapiens Protein: RCC1
Summary
InnateDB Protein IDBP-95235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCC1
Protein Name regulator of chromosome condensation 1
Synonyms CHC1; RCC1-I; SNHG3-RCC1;
Species Homo sapiens
Ensembl Protein ENSP00000362939
InnateDB Gene IDBG-95231 (RCC1)
Protein Structure
UniProt Annotation
Function Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. {ECO:0000269PubMed:1944575}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17435751}. Cytoplasm {ECO:0000269PubMed:17435751}. Note=Becomes dispersed throughout the cytoplasm during mitosis.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 104 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 104 [view]
Protein-Protein 104 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005087 Ran guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0031492 nucleosomal DNA binding
GO:0042393 histone binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitosis
GO:0016032 viral process
GO:0032853 positive regulation of Ran GTPase activity
GO:0051225 spindle assembly
Cellular Component
GO:0000790 nuclear chromatin
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR000408 Regulator of chromosome condensation, RCC1
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFAM PF00415
PRINTS PR00633
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P18754
PhosphoSite PhosphoSite-P18754
TrEMBL Q5T081
UniProt Splice Variant
Entrez Gene 1104
UniGene Hs.469723
RefSeq
HUGO HGNC:1913
OMIM 179710
CCDS CCDS323
HPRD 01559
IMGT
EMBL AF498924 AL513497 BC007300 BC010067 BC036903 BC069198 CH471059 CR407693 D00591 S75708 X06130 X12654
GenPept AAB32653 AAH07300 AAH10067 AAH36903 AAH69198 AAM21072 BAA00469 CAA29496 CAA31182 CAG28621 EAX07691 EAX07693

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca