InnateDB Protein
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IDBP-9532.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAX
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Protein Name
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MYC associated factor X
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Synonyms
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bHLHd4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000351175
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InnateDB Gene
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IDBG-9524 (MAX)
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Protein Structure
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Function |
Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.
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Subcellular Localization |
Nucleus. Cell projection, dendrite {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 817 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
817
[view]
|
Protein-Protein |
87
[view]
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Protein-DNA |
730
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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|
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Molecular Function |
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Biological Process |
GO:0006366
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transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
P61244
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PhosphoSite |
PhosphoSite-P61244
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TrEMBL |
G3V570
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UniProt Splice Variant |
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Entrez Gene |
4149
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UniGene |
Hs.285354
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RefSeq |
NP_660087
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HUGO |
HGNC:6913
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OMIM |
154950
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CCDS |
CCDS9772
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HPRD |
01113
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IMGT |
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EMBL |
AK290130
AK290929
AK292189
AK292630
AL139022
BC003525
BC004516
BC013669
BC027924
CH471061
M64240
X60287
X66867
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GenPept |
AAA36200
AAA36201
AAH03525
AAH04516
AAH13669
AAH27924
BAF82819
BAF83618
BAF84878
BAF85319
CAA42827
CAA47337
CAA47338
CAA47339
EAW80899
EAW80901
EAW80903
EAW80904
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