InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KPNA6

Summary

InnateDB Protein

IDBP-95577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KPNA6

Protein Name

karyopherin alpha 6 (importin alpha 7)

Synonyms

IPOA7; KPNA7;

Species

Homo sapiens

Ensembl Protein

ENSP00000362728

InnateDB Gene

IDBG-95575 (KPNA6)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269PubMed:10523667}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10523667}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006606	protein import into nucleus
GO:0006607	NLS-bearing protein import into nucleus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060135	maternal process involved in female pregnancy