InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDAC1

Summary

InnateDB Protein

IDBP-95714.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC1

Protein Name

histone deacetylase 1

Synonyms

GON-10; HD1; RPD3; RPD3L1;

Species

Homo sapiens

Ensembl Protein

ENSP00000362649

InnateDB Gene

IDBG-95712 (HDAC1)

Protein Structure

UniProt Annotation

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. {ECO:0000269PubMed:12837748, ECO:0000269PubMed:16478997, ECO:0000269PubMed:17000776, ECO:0000269PubMed:17704056, ECO:0000269PubMed:17996965, ECO:0000269PubMed:19081374, ECO:0000269PubMed:19343227}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 816 experimentally validated interaction(s) in this database.

Experimentally validated
Total	816 [view]
Protein-Protein	674 [view]
Protein-DNA	24 [view]
Protein-RNA	0
DNA-DNA	118 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019213	deacetylase activity
GO:0019899	enzyme binding
GO:0031492	nucleosomal DNA binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558	protein deacetylase activity
GO:0033613	activating transcription factor binding
GO:0042826	histone deacetylase binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006476	protein deacetylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0009913	epidermal cell differentiation
GO:0010467	gene expression
GO:0010870	positive regulation of receptor biosynthetic process
GO:0016032	viral process
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0032922	circadian regulation of gene expression
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0043044	ATP-dependent chromatin remodeling
GO:0043066	negative regulation of apoptotic process
GO:0043922	negative regulation by host of viral transcription
GO:0045087	innate immune response (InnateDB)
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0060789	hair follicle placode formation
GO:0061029	eyelid development in camera-type eye
GO:0061198	fungiform papilla formation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016580	Sin3 complex
GO:0016581	NuRD complex
GO:0043234	protein complex