Version 5.4
Homo sapiens Protein: TRIM62
Summary
InnateDB Protein IDBP-95890.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM62
Protein Name tripartite motif containing 62
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000291416
InnateDB Gene IDBG-95888 (TRIM62)
Protein Structure
UniProt Annotation
Function E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2. {ECO:0000269PubMed:23402750}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:23402750}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0032897 negative regulation of viral transcription
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0046596 regulation of viral entry into host cell
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1902186 regulation of viral release from host cell
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF00643
PF13639
PF14634
PF00622
PF13765
PF00097
PRINTS PR01407
PIRSF
SMART SM00336
SM00184
SM00449
SM00589
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BVG3
PhosphoSite PhosphoSite-Q9BVG3
TrEMBL
UniProt Splice Variant
Entrez Gene 55223
UniGene Hs.656006
RefSeq NP_060677
HUGO HGNC:25574
OMIM
CCDS CCDS376
HPRD 07697
IMGT
EMBL AK001621 AK122896 AL662907 BC001222 BC007999 BC011689 BC012152 CH471059
GenPept AAH01222 AAH07999 AAH11689 AAH12152 BAA91792 BAG53787 CAH70402 EAX07466 EAX07467

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca