Version 5.4
Homo sapiens Protein: PKIB
Summary
InnateDB Protein IDBP-96016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKIB
Protein Name protein kinase (cAMP-dependent, catalytic) inhibitor beta
Synonyms PRKACN2;
Species Homo sapiens
Ensembl Protein ENSP00000357433
InnateDB Gene IDBG-96012 (PKIB)
Protein Structure
UniProt Annotation
Function Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004862 cAMP-dependent protein kinase inhibitor activity
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR004171 cAMP-dependent protein kinase inhibitor
PFAM PF02827
PRINTS
PIRSF PIRSF001667
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C010
PhosphoSite PhosphoSite-Q9C010
TrEMBL
UniProt Splice Variant
Entrez Gene 5570
UniGene Hs.734380
RefSeq
HUGO HGNC:9018
OMIM 606914
CCDS CCDS5126
HPRD 06075
IMGT
EMBL AF087873 AF225513 AK315151 AL512283 AL513481 BC036011 BC093027 CH471051 Z99129
GenPept AAH36011 AAH93027 AAK00638 AAM10501 BAG37599 EAW48171

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca