Version 5.4
Homo sapiens Protein: GJA4
Summary
InnateDB Protein IDBP-96025.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GJA4
Protein Name gap junction protein, alpha 4, 37kDa
Synonyms CX37;
Species Homo sapiens
Ensembl Protein ENSP00000343676
InnateDB Gene IDBG-96023 (GJA4)
Protein Structure
UniProt Annotation
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Disease Associations
Tissue Specificity Expressed in multiple organs and tissues, including heart, uterus, ovary, and blood vessel endothelium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001568 blood vessel development
GO:0003158 endothelium development
GO:0006810 transport
GO:0006816 calcium ion transport
GO:0007043 cell-cell junction assembly
GO:0007267 cell-cell signaling
GO:0048265 response to pain
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000500 Connexin
IPR002263 Gap junction alpha-4 protein (Cx37)
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF10582
PRINTS PR00206
PR01134
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35212
PhosphoSite PhosphoSite-P35212
TrEMBL Q5JW71
UniProt Splice Variant
Entrez Gene 2701
UniGene Hs.296310
RefSeq NP_002051
HUGO HGNC:4278
OMIM 121012
CCDS CCDS30669
HPRD 08509
IMGT
EMBL AF132674 AF139100 AF139101 AF139102 AF139103 AF139104 AF139105 AF181620 AK291563 AL121988 BC027889 BC072389 CH471059 M96789
GenPept AAA52558 AAD31869 AAD31870 AAD31871 AAD31872 AAD31873 AAD31874 AAD56940 AAF62342 AAH27889 AAH72389 BAF84252 CAB90268 EAX07440 EAX07441

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca