InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOXO1

Summary

InnateDB Protein

IDBP-9611.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOXO1

Protein Name

NADPH oxidase organizer 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346195

InnateDB Gene

IDBG-9609 (NOXO1)

Protein Structure

UniProt Annotation

Function

Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269PubMed:12657628, ECO:0000269PubMed:14617635, ECO:0000269PubMed:15326186, ECO:0000269PubMed:15824103, ECO:0000269PubMed:15949904, ECO:0000269PubMed:16329988, ECO:0000269PubMed:17126813, ECO:0000269PubMed:19755710}.

Subcellular Localization

Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner.

Disease Associations

Tissue Specificity

Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. {ECO:0000269PubMed:12657628, ECO:0000269PubMed:15326186, ECO:0000269PubMed:15949904}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0016176	superoxide-generating NADPH oxidase activator activity
GO:0019899	enzyme binding
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding

Biological Process

GO:0010310	regulation of hydrogen peroxide metabolic process
GO:0022617	extracellular matrix disassembly
GO:0043085	positive regulation of catalytic activity
GO:0060263	regulation of respiratory burst