Version 5.4
Homo sapiens Protein: NCDN
Summary
InnateDB Protein IDBP-96176.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCDN
Protein Name neurochondrin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348394
InnateDB Gene IDBG-96172 (NCDN)
Protein Structure
UniProt Annotation
Function Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. {ECO:0000250, ECO:0000269PubMed:16945926}.
Subcellular Localization Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons.
Disease Associations
Tissue Specificity Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine. {ECO:0000269PubMed:10524216, ECO:0000269PubMed:9628581}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0031175 neuron projection development
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBB6
PhosphoSite PhosphoSite-Q9UBB6
TrEMBL C9J5H8
UniProt Splice Variant
Entrez Gene 23154
UniGene Hs.600737
RefSeq NP_001014839
HUGO HGNC:17597
OMIM 608458
CCDS CCDS392
HPRD 10530
IMGT
EMBL AB011179 AB018739 AB018740 AB027514 AC004865 AK295979 BC024592 CH471059
GenPept AAD05029 AAH24592 BAA25533 BAA77830 BAA77831 BAA85384 BAA85385 BAG58754 EAX07410 EAX07411 EAX07412

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca