Version 5.4
Homo sapiens Protein: ECHDC1
Summary
InnateDB Protein IDBP-96200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECHDC1
Protein Name enoyl CoA hydratase domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357274
InnateDB Gene IDBG-96186 (ECHDC1)
Protein Structure
UniProt Annotation
Function Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level. {ECO:0000269PubMed:22016388}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004492 methylmalonyl-CoA decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001753 Crotonase superfamily
IPR029045 ClpP/crotonase-like domain
PFAM PF00378
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NTX5
PhosphoSite PhosphoSite-Q9NTX5
TrEMBL
UniProt Splice Variant
Entrez Gene 55862
UniGene Hs.685427
RefSeq NP_060949
HUGO HGNC:21489
OMIM 612136
CCDS CCDS34530
HPRD 13260
IMGT
EMBL AF220192 AK303812 AL109939 AL834469 BC003549 CH471051 EU668355
GenPept AAF67657 AAH03549 ACF94508 BAH14056 CAB76256 CAD39128 CAI20295 CAI20297 CAI20298 CAI20302 EAW48107

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca