InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFAP2E

Summary

InnateDB Protein

IDBP-96216.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFAP2E

Protein Name

transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362332

InnateDB Gene

IDBG-96214 (TFAP2E)

Protein Structure

UniProt Annotation

Function

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:Q6VUP9}.

Disease Associations

Tissue Specificity

Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line. {ECO:0000269PubMed:14636996}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity