InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPL

Summary

InnateDB Protein

IDBP-9634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPL

Protein Name

lipoprotein lipase

Synonyms

HDLCQ11; LIPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000309757

InnateDB Gene

IDBG-9632 (LPL)

Protein Structure

UniProt Annotation

Function

The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Secreted {ECO:0000250}. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). {ECO:0000250}.

Disease Associations

Lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]: Recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. {ECO:0000269PubMed:10660334, ECO:0000269PubMed:10787434, ECO:0000269PubMed:11068186, ECO:0000269PubMed:11099402, ECO:0000269PubMed:11134145, ECO:0000269PubMed:11441134, ECO:0000269PubMed:12204001, ECO:0000269PubMed:12641539, ECO:0000269PubMed:12966036, ECO:0000269PubMed:1400331, ECO:0000269PubMed:1479292, ECO:0000269PubMed:14984478, ECO:0000269PubMed:15185149, ECO:0000269PubMed:1521525, ECO:0000269PubMed:15256764, ECO:0000269PubMed:15877202, ECO:0000269PubMed:1598907, ECO:0000269PubMed:1619366, ECO:0000269PubMed:1639392, ECO:0000269PubMed:1674945, ECO:0000269PubMed:1702428, ECO:0000269PubMed:1730727, ECO:0000269PubMed:1752947, ECO:0000269PubMed:1907278, ECO:0000269PubMed:1969408, ECO:0000269PubMed:1975597, ECO:0000269PubMed:2010533, ECO:0000269PubMed:2038366, ECO:0000269PubMed:2110364, ECO:0000269PubMed:2121025, ECO:0000269PubMed:7647785, ECO:0000269PubMed:7806969, ECO:0000269PubMed:7906986, ECO:0000269PubMed:7912254, ECO:0000269PubMed:7999071, ECO:0000269PubMed:8077845, ECO:0000269PubMed:8096693, ECO:0000269PubMed:8135797, ECO:0000269PubMed:8288243, ECO:0000269PubMed:8301230, ECO:0000269PubMed:8325986, ECO:0000269PubMed:8486765, ECO:0000269PubMed:8728326, ECO:0000269PubMed:8778602, ECO:0000269PubMed:8858123, ECO:0000269PubMed:8872057, ECO:0000269PubMed:8956048, ECO:0000269PubMed:8956052, ECO:0000269PubMed:9279761, ECO:0000269PubMed:9298816, ECO:0000269PubMed:9498099, ECO:0000269PubMed:9662394, ECO:0000269PubMed:9714430, ECO:0000269PubMed:9719626}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004465	lipoprotein lipase activity
GO:0004620	phospholipase activity
GO:0004806	triglyceride lipase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017129	triglyceride binding
GO:0034185	apolipoprotein binding
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006641	triglyceride metabolic process
GO:0006644	phospholipid metabolic process
GO:0007603	phototransduction, visible light
GO:0009409	response to cold
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010886	positive regulation of cholesterol storage
GO:0010890	positive regulation of sequestering of triglyceride
GO:0016042	lipid catabolic process
GO:0019432	triglyceride biosynthetic process
GO:0019433	triglyceride catabolic process
GO:0034371	chylomicron remodeling
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0042157	lipoprotein metabolic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0031225	anchored component of membrane
GO:0034361	very-low-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000734 Lipase
IPR001024 PLAT/LH2 domain
IPR002330 Lipoprotein lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF01477
PF00151

PRINTS

PR00821
PR00822

PIRSF

PIRSF000865

SMART

SM00308

TIGRFAMs

Post-translational Modifications

Modification

Cross-References