InnateDB Protein
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IDBP-96470.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDCA8
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Protein Name
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cell division cycle associated 8
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362146
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InnateDB Gene
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IDBG-96468 (CDCA8)
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Protein Structure
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Function |
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269PubMed:15249581, ECO:0000269PubMed:15260989, ECO:0000269PubMed:16571674, ECO:0000269PubMed:18243099}.
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Subcellular Localization |
Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
39
[view]
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Protein-Protein |
37
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018851
Borealin-like, N-terminal
IPR018867
Cell division protein borealin
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PFAM |
PF10444
PF10512
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q53HL2
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PhosphoSite |
PhosphoSite-Q53HL2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55143
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UniGene |
Hs.524571
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RefSeq |
NP_060571
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HUGO |
HGNC:14629
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OMIM |
609977
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CCDS |
CCDS424
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HPRD |
13017
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IMGT |
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EMBL |
AK001330
AK022104
AK022606
AK222549
AK222568
AY508815
BC000703
BC001651
BC008079
BC016944
BG354581
CH471059
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GenPept |
AAH00703
AAH01651
AAH08079
AAH16944
AAR91699
BAA91629
BAB13961
BAB14125
BAD96269
BAD96288
EAX07324
EAX07325
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