InnateDB Protein
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IDBP-96541.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MED23
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Protein Name
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mediator complex subunit 23
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Synonyms
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ARC130; CRSP130; CRSP133; CRSP3; DRIP130; MRT18; SUR-2; SUR2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357047
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InnateDB Gene
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IDBG-96537 (MED23)
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Protein Structure
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Function |
Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269PubMed:10353252, ECO:0000269PubMed:14759369, ECO:0000269PubMed:16595664}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Mental retardation, autosomal recessive 18 (MRT18) [MIM:614249]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:21868677}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
67
[view]
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Protein-Protein |
64
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0010467
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gene expression
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Cellular Component |
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PDB ID |
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InterPro |
IPR021629
Mediator complex, subunit Med23
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PFAM |
PF11573
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULK4
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PhosphoSite |
PhosphoSite-Q9ULK4
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TrEMBL |
B9TX51
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UniProt Splice Variant |
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Entrez Gene |
9439
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UniGene |
Hs.595435
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RefSeq |
NP_004821
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HUGO |
HGNC:2372
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OMIM |
605042
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CCDS |
CCDS5147
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HPRD |
05436
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IMGT |
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EMBL |
AB033042
AF104255
AF105332
AF135022
AL121575
AL136776
BC060759
CH471051
EU392522
EU392526
EU392532
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GenPept |
AAD12724
AAD30202
AAD31729
AAH60759
ACB88850
ACB88854
ACB88860
BAA86530
CAB66710
CAB92072
CAB92073
CAI23319
CAI23320
EAW48052
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