InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCF21

Summary

InnateDB Protein

IDBP-96739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCF21

Protein Name

transcription factor 21

Synonyms

bHLHa23; POD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000237316

InnateDB Gene

IDBG-96735 (TCF21)

Protein Structure

UniProt Annotation

Function

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0043425	bHLH transcription factor binding
GO:0046983	protein dimerization activity
GO:0050681	androgen receptor binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001763	morphogenesis of a branching structure
GO:0001822	kidney development
GO:0001944	vasculature development
GO:0006351	transcription, DNA-templated
GO:0007530	sex determination
GO:0014707	branchiomeric skeletal muscle development
GO:0030855	epithelial cell differentiation
GO:0032835	glomerulus development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048286	lung alveolus development
GO:0048536	spleen development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048608	reproductive structure development
GO:0048732	gland development
GO:0060008	Sertoli cell differentiation
GO:0060021	palate development
GO:0060425	lung morphogenesis
GO:0060426	lung vasculature development
GO:0060435	bronchiole development
GO:0060539	diaphragm development
GO:0060541	respiratory system development
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0072162	metanephric mesenchymal cell differentiation
GO:0072277	metanephric glomerular capillary formation