InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCLAF1

Summary

InnateDB Protein

IDBP-96923.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCLAF1

Protein Name

BCL2-associated transcription factor 1

Synonyms

bK211L9.1; BTF;

Species

Homo sapiens

Ensembl Protein

ENSP00000229446

InnateDB Gene

IDBG-96919 (BCLAF1)

Protein Structure

UniProt Annotation

Function

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269PubMed:18794151}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	51 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043620	regulation of DNA-dependent transcription in response to stress
GO:0045892	negative regulation of transcription, DNA-templated
GO:2000144	positive regulation of DNA-dependent transcription, initiation
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway