InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2D6

Summary

InnateDB Protein

IDBP-9698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2D6

Protein Name

cytochrome P450, family 2, subfamily D, polypeptide 6

Synonyms

CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000353820

InnateDB Gene

IDBG-9690 (CYP2D6)

Protein Structure

UniProt Annotation

Function

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. {ECO:0000269PubMed:16352597}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008144	drug binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0009804	coumarin metabolic process
GO:0009820	alkaloid metabolic process
GO:0009822	alkaloid catabolic process
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0033076	isoquinoline alkaloid metabolic process
GO:0042737	drug catabolic process
GO:0044281	small molecule metabolic process
GO:0046483	heterocycle metabolic process
GO:0051100	negative regulation of binding
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0090350	negative regulation of cellular organofluorine metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008069 Cytochrome P450, E-class, group I, CYP2D-like

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00465
PR01686

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite