InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL20RA

Summary

InnateDB Protein

IDBP-96987.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL20RA

Protein Name

interleukin 20 receptor, alpha

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000314976

InnateDB Gene

IDBG-96985 (IL20RA)

Protein Structure

UniProt Annotation

Function

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin. {ECO:0000269PubMed:11163236, ECO:0000269PubMed:14764663}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042015	interleukin-20 binding

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0045124	regulation of bone resorption
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway