InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YBX1

Summary

InnateDB Protein

IDBP-97233.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YBX1

Protein Name

Y box binding protein 1

Synonyms

BP-8; CSDA2; CSDB; DBPB; MDR-NF1; NSEP-1; NSEP1; YB-1; YB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000361626

InnateDB Gene

IDBG-97231 (YBX1)

Protein Structure

UniProt Annotation

Function

Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. {ECO:0000250}.The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 195 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	195 [view]
Protein-Protein	193 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000398	mRNA splicing, via spliceosome
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0051154	negative regulation of striated muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005689	U12-type spliceosomal complex
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0030529	ribonucleoprotein complex
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0070937	CRD-mediated mRNA stability complex
GO:0071204	histone pre-mRNA 3'end processing complex