InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLAGL1

Summary

InnateDB Protein

IDBP-97398.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLAGL1

Protein Name

pleiomorphic adenoma gene-like 1

Synonyms

LOT1; ZAC; ZAC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000346810

InnateDB Gene

IDBG-97390 (PLAGL1)

Protein Structure

UniProt Annotation

Function

Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. {ECO:0000269PubMed:18299245}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11313869, ECO:0000269PubMed:18299245}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter