InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SASH1

Summary

InnateDB Protein

IDBP-97669.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SASH1

Protein Name

SAM and SH3 domain containing 1

Synonyms

dJ323M4; dJ323M4.1; SH3D6A;

Species

Homo sapiens

Ensembl Protein

ENSP00000356437

InnateDB Gene

IDBG-97665 (SASH1)

Protein Structure

UniProt Annotation

Function

May have a role in a signaling pathway. Could act as a tumor suppressor.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. {ECO:0000269PubMed:12771949}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019901	protein kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0032947	protein complex scaffold

Biological Process

GO:0000209	protein polyubiquitination
GO:0010595	positive regulation of endothelial cell migration
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0045766	positive regulation of angiogenesis
GO:1900044	regulation of protein K63-linked ubiquitination
GO:1900745	positive regulation of p38MAPK cascade
GO:1901224	positive regulation of NIK/NF-kappaB signaling
GO:1902498	regulation of protein autoubiquitination

Cellular Component

GO:0016020	membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR011511 Variant SH3 domain
IPR013761 Sterile alpha motif/pointed domain
IPR021090 SAM/SH3 domain-containing
IPR021129 Sterile alpha motif, type 1

PFAM

PF00018
PF14604
PF07647
PF07653
PF12485
PF00536

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt