InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF220

Summary

InnateDB Protein

IDBP-97716.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF220

Protein Name

ring finger protein 220

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361321

InnateDB Gene

IDBG-97708 (RNF220)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0051865	protein autoubiquitination

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR011650 Peptidase M20, dimerisation domain

PFAM

PF13639
PF14634
PF07687

PRINTS

PIRSF

SMART

SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5VTB9

PhosphoSite

PhosphoSite-Q5VTB9

TrEMBL

D3DPZ1

UniProt Splice Variant

Entrez Gene

55182

UniGene

Hs.681897

RefSeq

XP_005271054

HUGO

HGNC:25552

OMIM

CCDS

HPRD

13336

IMGT

EMBL

AK001459 AK056424 AL122004 AL359373 AL596225 BC034221 BC098266 BC098300 CH471059

GenPept

AAH34221 AAH98266 AAH98300 BAA91704 BAG51705 CAH72320 CAI16124 CAI22343 EAX07037 EAX07039