InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KATNA1

Summary

InnateDB Protein

IDBP-97756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KATNA1

Protein Name

katanin p60 (ATPase containing) subunit A 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356381

InnateDB Gene

IDBG-97750 (KATNA1)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255HAMAP-Rule:MF_03023}.

Subcellular Localization

Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255HAMAP- Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly cytoplasmic. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008568	microtubule-severing ATPase activity
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0045502	dynein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001578	microtubule bundle formation
GO:0001764	neuron migration
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007067	mitotic nuclear division
GO:0008104	protein localization
GO:0010977	negative regulation of neuron projection development
GO:0031122	cytoplasmic microtubule organization
GO:0051013	microtubule severing
GO:0051329	interphase of mitotic cell cycle

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005811	lipid particle
GO:0005813	centrosome
GO:0005819	spindle
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030426	growth cone
GO:0030496	midbody
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR015415 Vps4 oligomerisation, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF09336

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75449