InnateDB Protein
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IDBP-97764.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KIF2C
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Protein Name
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kinesin family member 2C
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Synonyms
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CT139; KNSL6; MCAK;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361298
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InnateDB Gene
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IDBG-97762 (KIF2C)
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Protein Structure
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Function |
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. {ECO:0000269PubMed:19060894, ECO:0000269PubMed:21820309}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. {ECO:0000269PubMed:12383881, ECO:0000269PubMed:9434124}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
28
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001752
Kinesin, motor domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00225
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PRINTS |
PR00380
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PIRSF |
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SMART |
SM00129
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TIGRFAMs |
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Modification |
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SwissProt |
Q99661
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PhosphoSite |
PhosphoSite-Q99661
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TrEMBL |
Q8N5N1
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UniProt Splice Variant |
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Entrez Gene |
11004
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UniGene |
Hs.733568
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RefSeq |
NP_006836
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HUGO |
HGNC:6393
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OMIM |
604538
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CCDS |
CCDS512
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HPRD |
05172
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IMGT |
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EMBL |
AB264115
AK302267
AL592166
AY026505
BC008764
BC014924
BC032038
BT006759
CH471059
CR450302
U63743
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GenPept |
AAC27660
AAH08764
AAH14924
AAH32038
AAK20168
AAP35405
BAG50306
BAH13662
CAG29298
CAI12997
CAI12999
EAX07025
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