InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTHL1

Summary

InnateDB Protein

IDBP-9791.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTHL1

Protein Name

nth endonuclease III-like 1 (E. coli)

Synonyms

hNTH1; NTH1; OCTS3;

Species

Homo sapiens

Ensembl Protein

ENSP00000219066

InnateDB Gene

IDBG-9789 (NTHL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003824	catalytic activity
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0019104	DNA N-glycosylase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0045008	depyrimidination

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000445 Helix-hairpin-helix motif
IPR003265 HhH-GPD domain
IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif
IPR011257 DNA glycosylase

PFAM

PF00633
PF00730
PF10576

PRINTS

PIRSF

SMART

SM00478
SM00525

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P78549