InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDX1

Summary

InnateDB Protein

IDBP-97955.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX1

Protein Name

peroxiredoxin 1

Synonyms

MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262746

InnateDB Gene

IDBG-97953 (PRDX1)

Protein Structure

UniProt Annotation

Function

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 108 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	108 [view]
Protein-Protein	108 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005515	protein binding
GO:0008379	thioredoxin peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0051920	peroxiredoxin activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001501	skeletal system development
GO:0001895	retina homeostasis
GO:0006979	response to oxidative stress
GO:0008283	cell proliferation
GO:0019430	removal of superoxide radicals
GO:0032872	regulation of stress-activated MAPK cascade
GO:0034101	erythrocyte homeostasis
GO:0042267	natural killer cell mediated cytotoxicity
GO:0042345	regulation of NF-kappaB import into nucleus
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005719	nuclear euchromatin
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin
IPR019479 Peroxiredoxin, C-terminal

PFAM