InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LURAP1

Summary

InnateDB Protein

IDBP-98097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LURAP1

Protein Name

chromosome 1 open reading frame 190

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361048

InnateDB Gene

IDBG-98093 (LURAP1)

Protein Structure

UniProt Annotation

Function

Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21048106}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0016477	cell migration
GO:0031032	actomyosin structure organization
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling