InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSC2

Summary

InnateDB Protein

IDBP-9821.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSC2

Protein Name

tuberous sclerosis 2

Synonyms

LAM; PPP1R160; TSC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000371978

InnateDB Gene

IDBG-9819 (TSC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	115 [view]
Protein-Protein	112 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0019902	phosphatase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001843	neural tube closure
GO:0006469	negative regulation of protein kinase activity
GO:0006606	protein import into nucleus
GO:0006897	endocytosis
GO:0007050	cell cycle arrest
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007507	heart development
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016192	vesicle-mediated transport
GO:0030100	regulation of endocytosis
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032007	negative regulation of TOR signaling
GO:0032320	positive regulation of Ras GTPase activity
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043491	protein kinase B signaling
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response
GO:0046626	regulation of insulin receptor signaling pathway
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050918	positive chemotaxis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051726	regulation of cell cycle
GO:0051898	negative regulation of protein kinase B signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0033596	TSC1-TSC2 complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000331 Rap GTPase activating protein domain
IPR003913 Tuberin
IPR016024 Armadillo-type fold
IPR018515 Tuberin-type domain
IPR024584 Tuberin, N-terminal

PFAM

PF02145
PF03542
PF11864

PRINTS

PR01431

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49815