InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAF1

Summary

InnateDB Protein

IDBP-98415.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAF1

Protein Name

Fas (TNFRSF6) associated factor 1

Synonyms

hFAF1; HFAF1s; UBXD12; UBXN3A;

Species

Homo sapiens

Ensembl Protein

ENSP00000360843

InnateDB Gene

IDBG-98407 (FAF1)

Protein Structure

UniProt Annotation

Function

Potentiates but cannot initiate FAS-induced apoptosis.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 134 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	134 [view]
Protein-Protein	134 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019887	protein kinase regulator activity
GO:0019901	protein kinase binding
GO:0031072	heat shock protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0043130	ubiquitin binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006915	apoptotic process
GO:0007253	cytoplasmic sequestering of NF-kappaB
GO:0008219	cell death
GO:0031334	positive regulation of protein complex assembly
GO:0042176	regulation of protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045859	regulation of protein kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0031265	CD95 death-inducing signaling complex
GO:0034098	Cdc48p-Npl4p-Ufd1p AAA ATPase complex
GO:0048471	perinuclear region of cytoplasm