InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V1D

Summary

InnateDB Protein

IDBP-9842.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1D

Protein Name

ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000216442

InnateDB Gene

IDBG-9840 (ATP6V1D)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. {ECO:0000250, ECO:0000269PubMed:21844891}.

Subcellular Localization

Membrane {ECO:0000305PubMed:21844891}; Peripheral membrane protein {ECO:0000305PubMed:21844891}; Cytoplasmic side {ECO:0000305PubMed:21844891}. Note=Localizes to centrosome and the base of the cilium.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015992	proton transport
GO:0033572	transferrin transport
GO:0042384	cilium assembly
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0061512	protein localization to cilium
GO:0090382	phagosome maturation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005929	cilium
GO:0016020	membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0070062	extracellular vesicular exosome