Homo sapiens Protein: TXNDC12
Summary
InnateDB Protein IDBP-98581.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNDC12
Protein Name thioredoxin domain containing 12 (endoplasmic reticulum)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360688
InnateDB Gene IDBG-98579 (TXNDC12)
Protein Structure
UniProt Annotation
Function Possesses significant protein thiol-disulfide oxidase activity. {ECO:0000269PubMed:12761212}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000269PubMed:12761212}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:14557066}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0019153 protein-disulfide reductase (glutathione) activity
Biological Process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95881
PhosphoSite PhosphoSite-O95881
TrEMBL
UniProt Splice Variant
Entrez Gene 51060
UniGene
RefSeq NP_056997
HUGO HGNC:24626
OMIM 609448
CCDS CCDS561
HPRD 11633
IMGT
EMBL AF131758 AF543416 AK075409 AL445685 AY358982 BC001493 BC008913 BC008953
GenPept AAD20035 AAH01493 AAH08913 AAH08953 AAN34781 AAQ89341 BAG52132 CAI17031