InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAS1

Summary

InnateDB Protein

IDBP-98587.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAS1

Protein Name

MAS1 oncogene

Synonyms

MAS; MGRA;

Species

Homo sapiens

Ensembl Protein

ENSP00000252660

InnateDB Gene

IDBG-98585 (MAS1)

Protein Structure

UniProt Annotation

Function

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. {ECO:0000250, ECO:0000269PubMed:15809376, ECO:0000269PubMed:16611642}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16611642}; Multi-pass membrane protein {ECO:0000269PubMed:16611642}.

Disease Associations

Note=The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001595	angiotensin receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0017046	peptide hormone binding
GO:0042277	peptide binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0009653	anatomical structure morphogenesis
GO:0014823	response to activity
GO:0021766	hippocampus development
GO:0034698	response to gonadotropin
GO:0038166	angiotensin-activated signaling pathway
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0045740	positive regulation of DNA replication
GO:0050727	regulation of inflammatory response
GO:0060732	positive regulation of inositol phosphate biosynthetic process
GO:0070528	protein kinase C signaling
GO:0071375	cellular response to peptide hormone stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000820 Proto-oncogene Mas
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10328

PRINTS

PR00237
PR00533

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04201