InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFYVE9

Summary

InnateDB Protein

IDBP-98616.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFYVE9

Protein Name

zinc finger, FYVE domain containing 9

Synonyms

MADHIP; NSP; PPP1R173; SARA; SMADIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000360647

InnateDB Gene

IDBG-98606 (ZFYVE9)

Protein Structure

UniProt Annotation

Function

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269PubMed:15356634, ECO:0000269PubMed:9865696}.

Subcellular Localization

Cytoplasm. Early endosome membrane.

Disease Associations

Tissue Specificity

Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.

Experimentally validated
Total	75 [view]
Protein-Protein	75 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0008236	serine-type peptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006897	endocytosis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007183	SMAD protein complex assembly
GO:0007184	SMAD protein import into nucleus
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0005769	early endosome
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000306 FYVE zinc finger
IPR011011 Zinc finger, FYVE/PHD-type
IPR017165 Zinc finger, FYVE-type, SARA/endofin
IPR017455 Zinc finger, FYVE-related
IPR022557 Domain of unknown function DUF3480
IPR024608 Smad anchor for receptor activation, Smad-binding domain

PFAM

PF01363
PF11979
PF11409

PRINTS

PIRSF

PIRSF037289

SMART

SM00064

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt