InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZCCHC11

Summary

InnateDB Protein

IDBP-98640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZCCHC11

Protein Name

zinc finger, CCHC domain containing 11

Synonyms

PAPD3; TUT4;

Species

Homo sapiens

Ensembl Protein

ENSP00000360599

InnateDB Gene

IDBG-98638 (ZCCHC11)

Protein Structure

UniProt Annotation

Function

Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. {ECO:0000269PubMed:16643855, ECO:0000269PubMed:19703396}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016779	nucleotidyltransferase activity
GO:0044822	poly(A) RNA binding
GO:0050265	RNA uridylyltransferase activity

Biological Process

GO:0010586	miRNA metabolic process
GO:0010587	miRNA catabolic process
GO:0019827	stem cell maintenance
GO:0031054	pre-miRNA processing
GO:0031123	RNA 3'-end processing