Homo sapiens Protein: MAGOH
InnateDB Protein IDBP-98728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGOH
Protein Name mago-nashi homolog, proliferation-associated (Drosophila)
Synonyms MAGOH1; MAGOHA;
Species Homo sapiens
Ensembl Protein ENSP00000360525
InnateDB Gene IDBG-98726 (MAGOH)
Protein Structure
UniProt Annotation
Function Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. {ECO:0000269PubMed:12730685, ECO:0000269PubMed:16209946, ECO:0000269PubMed:22203037}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19324961}. Nucleus speckle {ECO:0000269PubMed:19324961}. Cytoplasm {ECO:0000269PubMed:19324961}. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous.
Number of Interactions This gene and/or its encoded proteins are associated with 202 experimentally validated interaction(s) in this database.
Experimentally validated
Total 202 [view]
Protein-Protein 198 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006406 mRNA export from nucleus
GO:0006417 regulation of translation
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
InterPro IPR004023 Mago nashi protein
PFAM PF02792
Post-translational Modifications
SwissProt P61326
PhosphoSite PhosphoSite-P61326
UniProt Splice Variant
Entrez Gene 55110
RefSeq NP_002361
OMIM 602603
HPRD 04005
EMBL AC021049 AF035940 AF067173 AK312113 AL606760 BC018211 CH471059
GenPept AAC39606 AAD32457 AAH18211 BAG35049 CAI18914 EAX06748